Aspirus seeks participants for cardiovascular disease trial

Aspirus Research Institute is seeking participants for a clinical study that has the potential to improve future treatment options for people living with cardiovascular disease.

If you have had a heart attack or stroke, or have poor circulation, you may be eligible for the study.

The REDEFINE 3 Study will look at the safety and potential benefits of cagrilintide and semaglutide (CagriSema) on cardiovascular events, like heart attack and stroke, in people living with cardiovascular disease. During the study, researchers will track cardiovascular events (heart attack, stroke or heart-related deaths) as well as changes in body weight and A1C.

Participants may qualify if they:

• Had a stroke, heart attack or have poor circulation (peripheral artery disease).

• Are 55 years of age or older.

• Are considered overweight or living with obesity (BMI greater than 25).

• Have type 2 diabetes.

• Can have chronic kidney disease.

• Can attend regular clinic visits and receive phone calls over 4-4½ years, depending on study start date.

The study sponsor, Novo Nordisk, expects the study to last up to four and a half years and enroll 7,000 participants in the United States and across the world.

“We are honored to be selected and participate in this important clinical trial that applies the latest research discoveries to help advance medicine,” said Aspirus study principal investigator interventional cardiologist German Larrain. “Study participants can know they are helping others by contributing to this important research.”

All patients enrolled in the study will be followed closely for up to four and a half years. There are no costs associated with participation, and patients are reimbursed for all study-related visits.

For more information, visit or call Aspirus Research Institute at 715-847-2273.